Taurolidine

CAS No.: 19388-87-5
Molecular Formula:C7H16N4O4S2
Molecular Weight:284.35
Density:1.467 g/cm3
Boiling Point:471.214 °C at 760 mmHg
Flash Point:238.782 °C
Purity: 99% min
Appearance: White powder
Description About Taurolidine CAS 19388-87-5
Taurolidine has been investigated for the prevention of Central Venous Catheter, Home Parenteral Nutrition, and Catheter-Related Infections.
Taurolidine is an antimicrobial that is used to try to prevent infections in catheters. Side effects and the induction of bacterial resistance is uncommon. It is also being studied as a treatment for cancer. It is derived from the endogenous amino acid taurine.
Taurolidine is an antimicrobial agent used in an effort to prevent catheter infections. It however is not approved for this use in the United States as of 2011.
Taurolidine is an antibacterial agent that can be used for the treatment of peritonis. It has also been used as an antiendoxic substance for systematic inflammatory response syndrome and as an anti-angiogenic agent for tumors. Furthermore, studies have reported that taurolidine can be used for the prevention of multiple catheter-related bloodstream infections.
Catheter lock solution in home parenteral nutrition (HPN) or total parenteral nutrition (TPN): catheter-related blood stream infections (CRBSI) remains the most common serious complication associated with long-term parenteral nutrition. The use of taurolidine as a catheter lock solution shows a reduction of CRBSI.The overall quality of the evidence however is not strong enough to justify routine use.
Catheter lock solution: Taurolidine decreases the adherence of bacteria and fungi to host cells by destructing the fimbriae and flagella and thus prevent the biofilm formation. Taurolidine is the active ingredient of antimicrobial catheter lock solutions for the prevention and treatment of catheter related bloodstream infections (CRBSIs) and is suitable for use in all catheter based vascular access devices. Bacterial resistance against taurolidine has never been observed in various studies.
The use of a taurolidine lock solution may decrease the risk of catheter infection in children with cancer but the evidence is tentative.