Sibutramine hydrochloride monohydrate is a white to off-white crystalline powder, or white cream crystalline powder, insoluble in water and soluble in grain alcohol.
Sibutramine (si-BYOO-tra-meen) is used together with a reduced-calorie diet to help you lose weight and to help keep the lost weight from returning.
Sibutramine is thought to work by increasing the activity of certain chemicals, called norepinephrine and serotonin, in the brain. This medicine is approved for use only in people who are very overweight.
Follow a reduced-calorie diet while taking sibutramine, as directed by your doctor. Sibutramine may be taken with or without food, on a full or empty stomach. However, if your doctor tells you to take it in a certain way, take it as directed.
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It is an orally administered agent for treatment of obesity. It mainly becomes effective through the metabolin of its amine （secondary amine and primary amine）, its main mechanism is increasing the feeling of satiation by controlling the reingestion of noradrenalin, serotonin 5-HT and dopamine, however, it has no evident effect on the release of noradrenalin, serotonin 5-HT and dopamine. Studies also shows that, this product and its amine activated metabolin have no evident prohibiting effects, such as, choline-resisting, histamine-resisting, and monoamine oxidase. Sibutramine is the first new weight-lreducing drug approved by FDA with recently 30 years. Therefore, its curative effect is safe and stable, is the most mature weight-reducing aid.
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