Linezolid is a bacterial protein synthesis inhibitor that acts on the bacterial 50S ribosomal subunit and is closest to the site of action. Unlike other drugs, linezolid does not affect the activity of peptidyl transferases, but acts on the initial stage of the translation system, inhibiting the connection of mRNA to ribosomes, preventing the formation of the 70S starting complex, thereby inhibiting bacterial protein synthesis. Linezolid is unique in the site and mode of action and is therefore not susceptible to cross-resistance to antimicrobials synthesized with other inhibitory proteins in positive bacteria with essential or acquired resistance characteristics and not susceptible to bacterial resistance in vitro The production.
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