Fluvastatin Sodium and intermediates

Fluvastatin Sodium and intermediates

Fluvastatin sodium is a commonly used lipid-lowering drugs, lipid-lowering effect is very good. Fluvastatin sodium is also a fully synthetic cholesterol-lowering drug and belongs to the inhibitor of methylglutaryl coenzyme A (HMC-CoA) reductase, which acts mainly in the liver and converts HMG-CoA to 3-methyl- 3,5-dihydroxyvaleric acid can inhibit the synthesis of endogenous cholesterol, reduce the content of cholesterol in hepatocytes, stimulate the synthesis of low density lipoprotein (LDL) receptor, increase the uptake of LDL particles and decrease the plasma total cholesterol concentration , Can significantly reduce total cholesterol, low density lipoprotein cholesterol, triglycerides, elevated high-density lipoprotein cholesterol.

 

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