Pregabalin is a 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.
Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin.
Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. It has also been found effective for generalized anxiety disorder and is (as of 2007) approved for this use in the European Union.It was designed as a more potent successor to gabapentin.Recent studies have shown that pregabalin is effective at treating chronic pain in disorders such as fibromyalgiaand spinal cord injury. In June 2007, pregabalin became the first medication approved by the U.S. Food and Drug Administration specifically for the treatment of fibromyalgia.
CAS NO.: 148553-50-8
Molecular Formula: C8H17NO2
Molecular weight: 159.229
Appearance: White to off-white crystalline powder
Assay Content by HPLC: Min. 98%-101%
Specific Rotation: + 10° ~+12°
Chloride: ≤ 0.1 %
Mesh size: 100% pass 80mesh
Solubility: Soluble in Ethanol
Loss on drying %: ≤ 1.0 %
Heavy metals: ≤20 PPM
Shelf Life: Two years if sealed and stored away from direct sun light.
Packing&Storage: Store in cool & dry place. Keep away from strong light and heat.
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