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New discovery of "molting hormone" from deerroot plant extracts has great anticancer potential

2020-07-16

Top picks: Extract, Anti-cancer, deer root

 

The main known role of deer root is to enhance physical strength and muscle protein synthesis. Its main acting factor is 20-hydroxyecdysone (also known as ecdysterone) and its analogs, which can be used during the molting and maturation of insects. It works and is called the ecdysone of the plant family. However, the results of a new study revealed that deer root extract has some anti-cancer activity.

 

Deer root is a traditional herbal medicine used to treat diseases in Siberia and Russia, and is widely grown in Russia and Eastern Europe. Deer root is a perennial herb. Its medicinal parts are mainly rhizomes, containing a variety of chemical components, mainly containing flavonoids, steroids, triterpenoid saponins, phenolic acids, volatile oils, and polysaccharides. , Used to treat neurasthenia and loss of appetite. In addition, it has the pharmacological effects of promoting cell growth, lowering blood fat, anti-atherosclerosis, bacteriostasis, strengthening the immune system, strengthening the body and regulating anti-stress. Deer root is thought to be close to ginseng and regulate blood pressure.

 

The main known role of deer root is to enhance physical strength and muscle protein synthesis. Its main acting factor is 20-hydroxyecdysone (also known as ecdysterone) and its analogs, which can be used during the molting and maturation of insects. It works and is called the ecdysone of the plant family. However, the results of a new study revealed that deer root extract has some anti-cancer activity.

 

Glioma accounts for nearly 80% of all primary malignant brain tumors, and its prognosis is worse and the mortality rate is higher. Glioblastoma is the most common type of glioma, divided into astrocytoma, oligodendroglioma, mixed oligotrophic neurocytoma and ependymoma. Glioma is an aggressive and most common major tumor of the central nervous system. The survival rate of patients after surgical resection of the tumor or chemotherapy is very low.

 

Approximately 13,000 primary deaths occur each year in the United States, and there are 18,000 new patients with primary malignant brain tumors. The average incidence rate of primary malignant brain tumor in adults over 20 years old is 9 per 100,000. In addition, gliomas are more common in men than women, and the gender difference is relatively small only in oligodendrogliomas. Although the age distribution of different glioma subtypes is different, the overall incidence of this type of tumor is driven by the most common type of glioma, and mainly refers to people over 20 years old. Therefore, at present, the epidemiology of gliomas proposes to prevent such diseases, and lack effective medical treatment.

 

In recent years, a variety of biologically active substances extracted from plants have shown multiple anticancer activities, so medical researchers have increasingly studied the anticancer activities of medicinal plants. Plant extracts and their secondary metabolites, especially alkaloids, polyphenols and terpenoids, can show anti-cancer activity by inhibiting cell proliferation, blocking the cell cycle and increasing cancer cell apoptosis. Plant raw materials are generally cheap and easy to obtain, and the existing toxicity may be extremely low, with high medicinal therapeutic value.

 

Deer root is a plant that has shown a variety of biological activities, including antioxidant, anti-cancer and anti-microbial effects, can eliminate physical and mental fatigue. Phytochemical studies have shown that deer root extract has certain anti-cancer activity and development potential. In a new study, it was determined that deer root plant extracts have primary cytotoxicity and apoptotic activity on human gliomas. It was found that deer root extract inhibited cell growth and induced apoptosis of human glioma cells in a dose-dependent manner. At the same time, it was found that deer root extract can up-regulate the pro-apoptotic Bax protein and down-regulate the anti-apoptotic Bcl-2 protein, thereby increasing the ratio of Bax/Bcl-2 protein levels.

 

To sum up, this preliminary study on deer root extract shows the important anti-cancer effect of the root extract of gramineous plants. As a natural medicinal material, deer root can not only enhance the body's immunity, inhibit the proliferation of cancer cells, but also cause certain cancer cells to undergo apoptosis, thereby inhibiting the proliferation of cancer cells and achieving the purpose of anti-cancer. Deer root extract may be an important source of potential anti-cancer prodrugs. It can be used as an adjuvant treatment for chemotherapy drugs, and is expected to play a role in combating cancer.


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