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Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

2020-04-24

The latest research by the team of Zhong Nanshan, an academician of the Chinese Academy of Engineering, believes that Lianhua Qingwen shows anti-new coronavirus in vitro tests. February 2020 Lianhua Qingwen Capsules (Particles) was included in the "New Coronavirus Pneumonia Diagnosis and Treatment Program (Sixth Edition)" by the National Health Commission

 

The related paper is entitled "Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)", which has been approved by Journal (Pharmacological Research) accepted. The paper mentions that Lianhua Qingwen has a broad-spectrum antiviral and immunomodulatory effect on a series of influenza viruses as a prescription for traditional Chinese medicine. Lianhua Qingwen significantly inhibited SARS-COV-2 replication, affected virus morphology and exerted anti-inflammatory activity in vitro. This shows that Lianhua Qingwen can resist virus attacks and is expected to become a new strategy for controlling COVID-19 disease.

 

main ingredient:

Forsythia, honeysuckle, ephedra, fried bitter almond, gypsum, Radix, Radix, Houttuynia cordata, patchouli, patchouli, rhubarb, Rhodiola, menthol, licorice Excipients: starch

 

The new coronavirus pneumonia belongs to the category of TCM epidemic. The honeysuckle is sweet and cold, and has a history of three thousand years of epidemic prevention and treatment. Since ancient times, it has been the first choice for major epidemics. Modern research has proved that honeysuckle has a broad-spectrum antiviral effect.

The team of Professor Zhang Chenyu of Nanjing University found that the miRNA rich in honeysuckle extract has the potential to target and inhibit new coronaviruses, which can be used for the early prevention and treatment of new coronaviruses. Subsequent studies have shown that MIR2911 in honeysuckle has binding sites in various viral genomes such as Ebola virus, Zika virus, African swine fever virus, Middle East respiratory fever virus and porcine rotavirus, which can inhibit the replication of these viruses.

 

The forsythia in the ingredients has the effects of clearing away heat and detoxifying, reducing swelling and loosening, and has been known as "the holy medicine for sores" since ancient times. Forsythia suspensa also has a broad-spectrum antibacterial effect. Forsythia phenol and volatile oil are the main components of its antibacterial activity, especially it has a strong inhibitory effect on a variety of pathogenic bacteria such as Staphylococcus aureus, Pneumococcus, various dysentery bacillus; The extract of Forsythia suspensa also has certain inhibitory effect against Coxsackie B virus and influenza virus, as well as anti-inflammatory and antipyretic effects.

 

Houttuynia cordata is a commonly used traditional Chinese medicine with the functions of clearing away heat and detoxifying, eliminating carbuncle and purging pus, and diuretic dialysis. It can be used for lung carbuncle (pulmonary abscess), chest pain, cough and pus and blood, lung heat cough, phlegm and qi, and heat poison Sore carbuncle, damp heat syndrome, etc.

Modern research has proved that Houttuynia cordata has good anti-inflammatory activity and can be used to treat respiratory tract infections; animal experiments have shown that Houttuynia cordata essential oil has a certain inhibitory effect on influenza virus. However, there is currently no definite evidence, especially no clinical trials to prove that Houttuynia cordata has a preventive effect on 2019-nCoV acute respiratory disease (new coronavirus-infected pneumonia).

 

Banlangen has the effects of clearing away heat and detoxifying, cooling blood, suitable for heat diseases such as wind-heat cold, sore throat and so on, and has a certain anti-viral effect. However, the new coronavirus is mainly based on wet evil, so from the pharmacological point of view, isatis is not suitable for early prevention, and there is no clear evidence that isatis is effective in preventing new coronaviruses.

Diammonium glycyrrhizinate is an extract of traditional Chinese medicine licorice. Its molecular structure is similar to steroid hormones. It can increase the activity of endogenous and exogenous glucocorticoids, inhibit excessive immune responses, and also protect the liver. It can suppress the excessive immune response and liver damage caused by the new coronavirus.

To effectively prevent the occurrence of new coronary pneumonia, it is recommended to avoid going out in crowded places. At the same time, you should pay attention to personal hygiene, wash your hands frequently, wear a mask, use sneezing or coughing to cover your mouth and nose with tissues or elbows, and at the same time, avoid contact and Fasting wild animals. If you have fever, cough and other symptoms, you should be vigilant, take good isolation and protection measures, and go to the fever clinic in time for medical treatment.


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