Hot Melt Extrusion For Pharmaceutical Manufacturers

by:Green Stone     2020-07-30
Hot melt extrusion is widely regarded as one of the best processing technologies contained in the food, plastic and rubber industries. The process was invented in late eighteenth century by an person called Joseph Brama and created for the process of manufacturing lead tubes. Sometime in the late 1850s, the technology was introduced towards plastics industry and gradually into the rubber and food industries. Today, hot melt extrusion has found a place in pharmaceutical manufacturing and they are currently used for the manufacture of various drugs including, pellets, granules, implants, ophthalmic inserts and sustained release tablets. Through hot melt extrusion, polymers can be shaped into a film, doing away with the established solvent-cast techniques. The focus on hot melt extrusion by pharmaceutical manufacturers in the publication rack mainly on the development of bio-enhanced formulations, forming solid solutions from water soluble drugs and mass manufacturing of drugs comprising pellets, beads, and transdermal systems. There are both advantages and cons of hot melt extrusion over more traditional drug manufacturing tricks. The Advantages of Extrusion Where pharmaceutical manufacturing is concerned, hot melt extrusion offers quite a few advantages over conventional manufacturing techniques. First of all, there are fewer steps required the actual world manufacturing of drugs and there are not any drying steps, which saves time and increases productivity. The method is simple which enable you to be carried out continuously and smoothly. As a reaction of the temperatures and intense mixing takes place throughout the manufacturing process, active ingredients are more evenly dispersed in the polymer, this leads to a better bioavailability. Through hot melt extrusion it may happen to manufacture an assortment of dosage forms, will be a big reason why contract pharma companies are choosing the process on a wider spectrum. The advantages certainly turn this into method of manufacture appealing when in comparison to traditional methods, but it is not without its downside. The Disadvantages of Extrusion Because on the fact going without shoes is a thermal process, there can be issues this API/polymer stability. Flow properties of the polymer are vital in proper processing along with the thermal manufacturing can sometimes become a subject. Also how many of the polymers can be limited because of the fact that polymers wanting to learn be processed at low temperatures. Equipment The hot melt extrusion equipment is the extruder, auxiliary equipment and a spread of monitoring tools tend to be used for evaluation and quality restraint. The extruder is the central part of the equipment and is completed up of: - Feeding hopper for ingredients - Barrels - Single/twin screws - Die and screw driving unit Auxiliary equipment consists of: - Hvac device for barrels - Conveyor belt - Solvent delivery pump Monitoring equipment gives specifics of the extrusion machine during processes; screw speed controllers, pressure and temperature gauges, and torque monitors all must be monitored closely to ensure the process is done correctly. Any mis-management of monitoring equipment could result in a faulty batch, which cost contract pharmaceutical manufacturers potentially millions of dollars.
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