Appearance: Light yellow or dark yellow powder
Synonyms: Methotrexate disodium salt; 7413-34-5; Sodium methotrexate; METHOTREXATE SODIUM; MTX disodium
CAS NO.: 7413-34-5
Molecular Formula: C20H20N8Na2O5
Molecular Weight: 498.411
Use: Animal Pharmaceuticals
Shelf life:3 Years
Storage:Sealed in a cool dry environment at 0-6℃
Main Function: pharmaceutical intermediate
Application: pharma grade or research purpose
Place of Origin: China
Payment Term: T/T 100% paid in advance
Active Pharmaceutical Ingredients High-Purity Methotrexate Disodium
Methotrexate Sodium is the sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Methotrexate Sodium is used to treat cancer cells, also known as poison, in order to reduce the toxicity of cytotoxic, with leucovorin used together, mainly used for the treatment of acute leukemia (acute lymphoblastic leukemia), breast cancer, choriocarcinoma and malignant mole, head and neck cancer, bone tumor, meningeal leukemia spinal cord infiltration, lung cancer, reproductive system tumor, liver cancer, refractory common psoriasis, dermatomyositis, body myositis, ankylosing spondylitis, Crohn's disease, psoriasis and psoriatic arthritis, Behcet's disease and autoimmune disease. Methotrexate is also an immunosuppressant, which can relieve the rheumatic process, and is especially effective in the treatment of synovitis of rheumatoid arthritis. It is one of the most widely used drugs in patients with rheumatoid diseases. The main side effects of methotrexate include nausea, vomiting and diarrhea, impaired liver function, oral ulcers, pneumonia, sepsis, and Kaposi's, mild fatigue and headaches, and dry skin.
Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant properties.
Ecological data: This substance may be harmful to the environment and specific attention should be paid to water bodies.
Nature and stability: It will not decompose if used and stored in accordance with specifications.
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