Grade: Pharmaceutical Grade
Synonym: Dadibutol, Myambutol; Ethambutol dihydrochloride
Chemical Name: 1-Butanol,2,2'-(ethylenediimino)di-,dihydrochloride,(+)-
CAS NO.: 1070-11-7
Molecular Formula: C10H26Cl2N2O2
Molecular Weight: 277.23
Appearance: White Powder
Melting Point: 201°C (393.8°F)
Solubility: Easily soluble in cold water, hot water. Soluble in alcohol.
Ethambutol hydrochloride is an antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. Ethambutol Hydrochloride is the hydrochloride salt form of ethambutol, an ethylenediamine derivative with antibacterial activity, specifically effective against mycobacteria. Although the exact mechanism of action of ethambutol hydrochloride is unknown, ethambutol hydrochloride inhibits the transfer of mycolic acids into the cell wall of bacteria, which impedes bacterial cell growth. This agent may also interfere with RNA synthesis or inhibit other cell metabolism, thereby preventing cell multiplication and causing cell death.
Ethambutol Hydrochloride which is a medicine for the treatment of tuberculosis. This drug has a strong inhibitory effect on Mycobacterium tuberculosis, no cross-resistance with other anti-tuberculosis drugs, and its antibacterial effect is weaker than isoniazid, and is ineffective against other bacteria and fungi. Ethambutol hydrochloride is used in the treatment of invalid tuberculosis patients such as isoniazid and streptomycin, and has a strong inhibitory effect on Mycobacterium tuberculosis and other mycobacteria. Oral absorption of about 80%, peak plasma concentration of 2 to 4 hours, protein binding of about 40% in the body only about 10% of the drug metabolism into inactive matter. Mainly excreted by the kidneys. There is no cross-resistance with other anti-tuberculosis drugs. However, Mycobacterium tuberculosis can also slowly develop resistance to this product. As second-line anti-tuberculosis drugs, they can be used in cases where other anti-tuberculosis drugs are not effective. They are often used in combination with other anti-tuberculosis drugs to enhance the efficacy and delay the development of bacterial drug resistance.
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