Endothelin Antagonists

Endothelin Antagonists

Pale yellow frozen dry powder
Product Specification
Place of Origin
1 kg
Payment Term
T/T 100% paid in advance
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Endothelin Antagonists

Endothelin Antagonists is an additive of new category for lightening cosmetics. During the middle of 1990s the dermato-physiologists found that the keratoid cells of human skins would release endothelin after being irradiated by the ultraviolet rays, the endothelin is accepted by the receptor on the melanocyte membrane exciting the differantiation and proliferation of the melanocyte, and activating the activity of tyrosinase, then the amount of melanin is thus drastically increased. After Endothelin Antagonist having entered into the skins, it combines with the receptor of the melanocyte membrane to inhibit the influence exerted by endothelin toward melanin, so that an instant beautifying effect of high efficieney is indicated.



Synonyms: n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
CAS NO.:  147536-97-8
MF:    C27H29N5O6S
MW: 551.61
Purity:  99%,98%

Boiling point: 742.3 ° C at 760 mmHg 
Flash Point: 402.8 ° C 
Vapor Pressure: 3.84E-23mmHg at 25 ° C

1. The natural product of high scientific technology: to process from natural products through
extraction, isolation and purification of high and new technology.
2. Non-poisonous, non-irritant and non-allergic.
3. Stable, light-resistant, heat-resistant, and no variation in the extent of pH 3~ 9.
4. Molecular weight of the active matter under 1000, with good epidermal penetration quality.

Main Function

The main reason of color mottle is the maldistribution of endothelin.When the Endothelin Antagonists enter into skin, it can combine with the melanin cytomembrane and then cause endothelin lost its function. 


Packing Method Recommended


Drum, Vacuum Packed


Recommendatory volumes of usage 0.02 to 0.10% .


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