Diammonium Glycyrrhizinate

Product Name: Diammonium Glycyrrhizinate

Appearance: White Powder

Specification: 5%-98%

Test Method: HPLC

Shelf Life: 2 Years

Storage: Cool Dry Place

CAS no.:79165-06-3
Molecular Formula:C42H62O16.2H3N
Molecular Weight:856.997
Purity: 97.0%～103.0%
Product description: It is anti-inflammatory, and it can protect liver cell membrane and improve liver function.

Diammonium Glycyrrhizinate ,Main use ,anti-inflammatory, improving liver function improvement, protect liver tissue and cure hep.

Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). The liquorices exert an important function in the treatment of hepatitis because of its anti-inflammatory effects based upon the clinical practice, but the underlying mechanism is unclear. In this study, we investigated the mechanisms of DG in protecting mice from ConA-induced hepatitis. The results showed that intraperitoneal administration of DG protected mice against ConA-induced elevation of serum ALT levels and apoptosis of hepatocytes; at the same time, the absolute amount of hepatic NKT cells and T cells was significantly decreased, indicating that DG can inhibit the recruitment of lymphocytes into the liver. In addition, the production of IL-6 and IL-10 was improved by DG pretreatment, suggesting that DG may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way.

Diammonium glycyrrhizinate, an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, the main and sweet component of licorice, has been studied for its ability to cause hypermineralocorticoidism with potassium loss and sodium retention, edema, increased blood pressure, as well as inhibited the renin-angiotensin-aldosterone system.