Cefbuperazone

Cefbuperazone

Appearance
White Powder
Place of Origin
China
MOQ
1 kg
Payment Term
T/T 100% paid in advance
Price
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Cefbuperazone

Grade: Pharmaceutical Grade
CAS NO.: 76610-84-9 
Molecular Formula: C22H29N9O9S2
Molecular weight: 627.648
Appearance: White Powder
Water content: Not more than1.0%
pH: Between4.0~6.0
Heavy metals:  Not more than 10ppm
Arsenic:  Not more than 2ppm
Absorbance(265nm): Between255~285
Sulphated ash: Not more than 0.2%
Specific optical Rotation: +48°~ +56°
Purity:  NLT99.0%

 

Cefbuperazone is a semisynthetic second-generation cephalosporin with antibacterial activity. Cefbuperazone binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.


Storage:  Store in a tightly closed container at low temperature.

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Function and Application

      

   

Used to cure Septicemia, chronic bronchitis, pneumonia, pulmonary purulent disease, endocarditis, cholecystitis caused by sensitive bacteria such as Escherichia coli, Serratia, common and exotic proteobacteria, Haemophilus influenzae, pneumococcal bacteria , peritonitis, cystitis, etc.

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Pharmacological Action

Cefbuperazone is a broad-spectrum bactericidal cephalosporin, which inhibits the synthesis of bacterial cell wall in the proliferative phase and produces bactericidal action. It also has strong activity against β-lactamase-producing bacteria, high drug concentration in vivo and plasma, and action time. More durable. It has antibacterial activity against Gram-positive and Gram-negative bacteria, and is more active than negative cefmetazole 2 to 32 times, especially for negative bacilli such as Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus, Serratia, genus bacillus, Enterobacter, and citrate have strong activity, and the effect on genus Proteus is stronger than cefoxitin. It also has good activity against fragile bacilli, melanin-producing bacterium, anaerobic cocci, Clostridium and some Clostridium. The plasmid or chromosome-mediated β-lactamase is highly stable, and the beta-lactamase produced by Bacteroides fragilis is more stable than other cephalosporins. However, a variety of Bacteroides and Fusobacterium are resistant to cefradine.

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